Seeing Molecules

http://sciencematters.berkeley.edu/archives/volume4/issue25/story3.php

Yang is developing a better way to study biomolecules in motion. "What we hope is to visualize chemistry one molecule at a time."
For this feat, Yang uses a technique called single-molecule microscopy. The method employs probes that fluoresce red or blue when excited by a photon of light. The blue one can acquire photons from an external light source, while the red one only accepts photons from its blue counterpart. For his experiments, Yang affixes one blue and one red probe to opposite ends of a study enzyme. When the enzyme is relaxed, and both probes are far apart, the assembly glows blue. When the
enzyme closes, the blue probe can pass along its photon, and the assembly glows red.

Ultimately, Yang's work could result in advances in disease research, drug design, turbulence, materials analysis, and even our grasp of basic biochemical reactions. Says Yang, "I hope that in doing these experiments, we will get the chance to know how nature makes these things happen, and take that understanding to improve our quality of life."

Medical transformation is founded on advances like this are fundamental processes can first be observed and confirmed.