Simulation Based Research by Henry Markham

Henry Markham proposes 'simulation based research'  

1. Reverse Engineer natural processes.


2. Generate Neurons


3. Reverse Engineer Electrical Types.


4. Molecular Basis of Electrical Diversity


5. Forward Engineering Single Neuron Models


6. Probe Neuron Models


7. The channelome project

The human “channelome,”  comprises families of
membrane ion channel proteins regulating bodily functions—some
400 genes, mixed and matched.

1. Placing snapses


2. 
   
   
   
   1. Blue Builder Simulation Package
   
   
   
   


3. Capturing snaptic transmission


4. 
   
   
   
   1. 6 types of snapsis
   
   
   2. anatomy of Martinotti Loops
   
   
   
   


5. Network Activity


6. 
   
   
   
   1. Most processing is analog
   
   
   2. 
      
   
   
   
   

Blue Brain has no hypothesis so it had funding problems in the US.

Emergent properties

1.     Consciousness?

IT challenge

1. workflows


2. supercomputers


3. build neurons


4. VISUALIZATION


5. 
   
   
   
   1. INTERACTIVE VISUALIZATION
   
   
   2. Analysis
   
   
   
   

Blue Brain is a facility to build circuits 

1.         The future is virtual labs

Funding is trivial

1.     over 1000 different diseases affected by the brain circuits